2026 Eastern States Conference

Title: Retrospective evaluation of desmopressin administration on hematoma expansion in traumatic intracranial hemorrhage in patients with suspected platelet dysfunction
Authors: Sadie Keener, PharmD; Olivia Iskaros, PharmD, BCCCP; Gene Berkovich, MD; Samuel Hawkins, MD; Ilana Gimelbrand, PharmD, BCCCP
Learning Objective: At the end of the presentation, the audience will be able to assess the impact of desmopressin administration on hematoma expansion in patients with traumatic intracranial hemorrhage at our institution.
Self-Assessment Question: What patient characteristics or conditions may contribute to platelet dysfunction?
1. Antiplatelet agents
2. Uremia
3. Liver Dysfunction
4. All of the above
Background: Limited evidence exists on the efficacy of desmopressin administration for platelet dysfunction in traumatic intracranial hemorrhage. The purpose of this study is to assess the effect of desmopressin on hematoma expansion upon repeat imaging in this patient population.
Methods: This is a retrospective cohort study of adult patients presenting to the emergency department with traumatic intracranial hemorrhage (ICH) and presumed platelet dysfunction at NYU Langone Hospital - Brooklyn from January 2020 to March 2025. Patients were stratified based on receipt of desmopressin versus no desmopressin. Patients were excluded if they had a secondary cause of ICH, no repeat brain imaging within 24 hours, neurosurgical intervention prior to repeat imaging, chronic therapeutic anticoagulation, Glasgow Coma Scale < 5, or catastrophic injury deemed nonsurvivable based on early clinical findings. The primary outcome is hematoma expansion upon repeat imaging defined by any hematoma expansion from baseline or a new hematoma not present on initial image. Secondary outcomes include hemostatic efficacy and survival to hospital discharge. Safety outcomes include ischemic stroke, venous thromboembolism, or hyponatremia within 7 days of desmopressin administration.
Results: TBD
Conclusion: TBD
  

---