Evaluation and Optimization of Sterile Compounding Dispense Prep Compliance Oleksandra Katrych, Medication Use and Standards, Pharmacy Lead Timothy J Clark, Pharmacy Resident Kelly J Miltner, Pharmacy Supervisor for sterile compounding Learning Objective: Describe the benefits of a barcode scanning as part of the sterile product preparation process. Background/Objective Identify current rates of barcode scanning compliance as part of a computer assisted sterile compounding workflow and develop targeted interventions for improving rates of scanning compliance to ensure proper component selection and improve patient safety. Methods This was a single center, retrospective, quasi-experimental pre–post study evaluating the impact of targeted interventions on the rate of sterile medications prepared that are missing a component barcode scan barcode scanning from April 1, 2025 to May 31, 2025 with a post intervention data set from April 10, 2026 to May 8, 2026. Medication preparations were categorized by medication name and if they were missing one or more component barcode scans. Order data was additionally reviewed to identify if a picture was taken during product preparation that could be used to identify the components that were not scanned. Results Among 7398 sterile products prepared during the initial time frame, 57 (0.77%) preparations were identified as missing at least one component barcode scan. The 57 identified preparations were represented by 14 different medications. Of the 57 preparations, 23 (54.39%) did not have an associated image, 3 (5.26%) contained picture but not of the component missing a scan, and the remaining 31 (40.35%) contained images that could be used to positively identify the product that was missing a barcode scan. Four weeks after intervention rates of barcode scanning compliance were found to be 99.57% with 14 preparations being identified out of 3,267 as missing as scan. The missing scans were limited to 3 different products. Conclusion(s) Barcode scanning during sterile product preparation is a reliable way to ensure proper product selection and enhance patient safety. While overall barcode scanning compliance at this institution was above 99%, targeted interventions aimed at medications and channels for reporting identified issues allowed for improvements in scanning compliance and helped identify potential future improvements in product design to ensure ease of barcode scanning. Self-Assessment Question Which of the following is NOT a benefit of barcode scanning technologies? - Enhanced patient safety - Improved product selection accuracy - Decreased product preparation time - Computerized tracking of products within the electronic health record